Adenoviral delivery of pan-caspase inhibitor p35 enhances bystander killing by P450 gene-directed enzyme prodrug therapy using cyclophosphamide(+)

BACKGROUND: Cytochrome P450-based suicide gene therapy for cancer using prodrugs such as cyclophosphamide (CPA) increases anti-tumor activity, both directly and via a bystander killing mechanism. Bystander cell killing is essential for the clinical success of this treatment strategy, given the diffi...

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Detalles Bibliográficos
Autores principales: Doloff, Joshua C, Su, Ting, Waxman, David J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946310/
https://www.ncbi.nlm.nih.gov/pubmed/20836875
http://dx.doi.org/10.1186/1471-2407-10-487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946310/
https://www.ncbi.nlm.nih.gov/pubmed/20836875
http://dx.doi.org/10.1186/1471-2407-10-487

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