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Transcriptional profiling of ErbB signalling in mammary luminal epithelial cells - interplay of ErbB and IGF1 signalling through IGFBP3 regulation

BACKGROUND: Members of the ErbB family of growth factor receptors are intricately linked with epithelial cell biology, development and tumourigenesis; however, the mechanisms involved in their downstream signalling are poorly understood. Indeed, it is unclear how signal specificity is achieved and t...

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Detalles Bibliográficos
Autores principales: Worthington, Jenny, Bertani, Mariana, Chan, Hong-Lin, Gerrits, Bertran, Timms, John F
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946312/
https://www.ncbi.nlm.nih.gov/pubmed/20840765
http://dx.doi.org/10.1186/1471-2407-10-490