Identification of Novel p53 Pathway Activating Small-Molecule Compounds Reveals Unexpected Similarities with Known Therapeutic Agents

Manipulation of the activity of the p53 tumor suppressor pathway has demonstrated potential benefit in preclinical mouse tumor models and has entered human clinical trials. We describe here an improved, extensive small-molecule chemical compound library screen for p53 pathway activation in a human c...

Descripción completa

Detalles Bibliográficos
Autores principales: Peltonen, Karita, Colis, Laureen, Liu, Hester, Jäämaa, Sari, Moore, Henna M., Enbäck, Juulia, Laakkonen, Pirjo, Vaahtokari, Anne, Jones, Richard J., af Hällström, Taija M., Laiho, Marikki
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946317/
https://www.ncbi.nlm.nih.gov/pubmed/20885994
http://dx.doi.org/10.1371/journal.pone.0012996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946317/
https://www.ncbi.nlm.nih.gov/pubmed/20885994
http://dx.doi.org/10.1371/journal.pone.0012996

Ejemplares similares