IκBβ acts to both inhibit and activate gene expression at different stages of the inflammatory response

The activation of pro-inflammatory gene programs by nuclear factor-κB (NF-κB) is primarily regulated through cytoplasmic sequestration of NF-κB by the inhibitor of κB (IκB) family of proteins1. IκBβ, a major IκB isoform, can sequester NF-κB in the cytoplasm2, although its biological role remains unc...

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Detalles Bibliográficos
Autores principales: Rao, Ping, Hayden, Mathew S., Long, Meixiao, Scott, Martin L., West, A. Philip, Zhang, Dekai, Oeckinghaus, Andrea, Lynch, Candace, Hoffmann, Alexander, Baltimore, David, Ghosh, Sankar
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946371/
https://www.ncbi.nlm.nih.gov/pubmed/20740013
http://dx.doi.org/10.1038/nature09283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946371/
https://www.ncbi.nlm.nih.gov/pubmed/20740013
http://dx.doi.org/10.1038/nature09283

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