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IκBβ acts to both inhibit and activate gene expression at different stages of the inflammatory response
The activation of pro-inflammatory gene programs by nuclear factor-κB (NF-κB) is primarily regulated through cytoplasmic sequestration of NF-κB by the inhibitor of κB (IκB) family of proteins1. IκBβ, a major IκB isoform, can sequester NF-κB in the cytoplasm2, although its biological role remains unc...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946371/ https://www.ncbi.nlm.nih.gov/pubmed/20740013 http://dx.doi.org/10.1038/nature09283 |