Dereplication of Macrocyclic Trichothecenes from Extracts of Filamentous Fungi through UV and NMR Profiles

Macrocyclic trichothecenes, which have potent cytotoxicity, have been isolated from many different fungal species. These compounds were evaluated clinically by the U.S. National Cancer Institute in the 1970's and 1980's. However, they have yet to be advanced into viable drugs due to severe...

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Detalles Bibliográficos
Autores principales: Sy-Cordero, Arlene A., Graf, Tyler N., Wani, Mansukh C., Kroll, David J., Pearce, Cedric J., Oberlies, Nicholas H.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946446/
https://www.ncbi.nlm.nih.gov/pubmed/20648023
http://dx.doi.org/10.1038/ja.2010.77

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946446/
https://www.ncbi.nlm.nih.gov/pubmed/20648023
http://dx.doi.org/10.1038/ja.2010.77

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