Compromized geranylgeranylation of RhoA and Rac1 in mevalonate kinase deficiency

Mevalonate kinase deficiency (MKD) is an autoinflammatory disorder caused by mutations in the MVK gene resulting in decreased activity of the enzyme mevalonate kinase (MK). Although MK is required for biosynthesis of all isoprenoids, in MKD, in particular, the timely synthesis of geranylgeranyl pyro...

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Detalles Bibliográficos
Autores principales: Henneman, L., Schneiders, M. S., Turkenburg, M., Waterham, H. R.
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946549/
https://www.ncbi.nlm.nih.gov/pubmed/20814828
http://dx.doi.org/10.1007/s10545-010-9173-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946549/
https://www.ncbi.nlm.nih.gov/pubmed/20814828
http://dx.doi.org/10.1007/s10545-010-9173-8

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