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Clustering-based identification of clonally-related immunoglobulin gene sequence sets

BACKGROUND: Clonal expansion of B lymphocytes coupled with somatic mutation and antigen selection allow the mammalian humoral immune system to generate highly specific immunoglobulins (IG) or antibodies against invading bacteria, viruses and toxins. The availability of high-throughput DNA sequencing...

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Detalles Bibliográficos
Autores principales: Chen, Zhiliang, Collins, Andrew M, Wang, Yan, Gaëta, Bruno A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946782/
https://www.ncbi.nlm.nih.gov/pubmed/20875155
http://dx.doi.org/10.1186/1745-7580-6-S1-S4