Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21

The Helicobacter pylori CagA bacterial oncoprotein plays a critical role in gastric carcinogenesis. Upon delivery into epithelial cells, CagA causes loss of polarity and activates aberrant Erk signaling. We show that CagA-induced Erk activation results in senescence and mitogenesis in nonpolarized a...

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Detalles Bibliográficos
Autores principales: Saito, Yasuhiro, Murata-Kamiya, Naoko, Hirayama, Toshiya, Ohba, Yusuke, Hatakeyama, Masanori
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947069/
https://www.ncbi.nlm.nih.gov/pubmed/20855497
http://dx.doi.org/10.1084/jem.20100602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947069/
https://www.ncbi.nlm.nih.gov/pubmed/20855497
http://dx.doi.org/10.1084/jem.20100602

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