Cargando…

Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21

The Helicobacter pylori CagA bacterial oncoprotein plays a critical role in gastric carcinogenesis. Upon delivery into epithelial cells, CagA causes loss of polarity and activates aberrant Erk signaling. We show that CagA-induced Erk activation results in senescence and mitogenesis in nonpolarized a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saito, Yasuhiro, Murata-Kamiya, Naoko, Hirayama, Toshiya, Ohba, Yusuke, Hatakeyama, Masanori
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947069/ https://www.ncbi.nlm.nih.gov/pubmed/20855497 http://dx.doi.org/10.1084/jem.20100602

Ejemplares similares

Evolution of cagA Oncogene of Helicobacter pylori through Recombination
por: Furuta, Yoshikazu, et al.
Publicado: (2011)

Helicobacter pylori CagA oncoprotein interacts with SHIP2 to increase its delivery into gastric epithelial cells
por: Fujii, Yumiko, et al.
Publicado: (2020)

Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein
por: Suzuki, Nobumi, et al.
Publicado: (2015)

Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA
por: Shimoda, Asako, et al.
Publicado: (2016)

Natural variant of the Helicobacter pylori CagA oncoprotein that lost the ability to interact with PAR1
por: Hashi, Kana, et al.
Publicado: (2014)

Mouse Gastric Epithelial Cells Resist CagA Delivery by the Helicobacter pylori Type IV Secretion System
por: Shrestha, Rejina, et al.
Publicado: (2022)

Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpin gastric carcinogenesis
por: Takahashi-Kanemitsu, Atsushi, et al.
Publicado: (2019)

Characterizing Helicobacter pylori cagA in Myanmar
por: Myint, Thein, et al.
Publicado: (2018)

Helicobacter pylori CagA Triggers Expression of the Bactericidal Lectin REG3γ via Gastric STAT3 Activation
por: Lee, Kai Syin, et al.
Publicado: (2012)

Impact of structural polymorphism for the Helicobacter pylori CagA oncoprotein on binding to polarity-regulating kinase PAR1b
por: Nishikawa, Hiroko, et al.
Publicado: (2016)

CEACAM6 is upregulated by Helicobacter pylori CagA and is a biomarker for early gastric cancer
por: Roy, Rony K., et al.
Publicado: (2016)

Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer
por: HATAKEYAMA, Masanori
Publicado: (2017)

CagA(+) Helicobacter pylori, Not CagA(–) Helicobacter pylori, Infection Impairs Endothelial Function Through Exosomes-Mediated ROS Formation
por: Xia, Xiujuan, et al.
Publicado: (2022)

Sequence Polymorphism and Intrinsic Structural Disorder as Related to Pathobiological Performance of the Helicobacter pylori CagA Oncoprotein
por: Nishikawa, Hiroko, et al.
Publicado: (2017)

Dramatic increase in SHP2 binding activity of Helicobacter pylori Western CagA by EPIYA-C duplication: its implications in gastric carcinogenesis
por: Nagase, Lisa, et al.
Publicado: (2015)

Conformational Analysis of Isolated Domains of Helicobacter pylori CagA
por: Woon, Amanda P., et al.
Publicado: (2013)

Mixed Infection with cagA Positive and cagA Negative Strains of Helicobacter pylori Lowers Disease Burden in The Gambia
por: Secka, Ousman, et al.
Publicado: (2011)

Structural Analysis of Variability and Interaction of the N-terminal of the Oncogenic Effector CagA of Helicobacter pylori with Phosphatidylserine
por: Ulloa-Guerrero, Cindy P., et al.
Publicado: (2018)

Response to ‘Helicobacter pylori infection of AZ-521 cells reveals a type IV secretion defect and VacA-independent CagA phosphorylation’
por: Nakano, Masayuki, et al.
Publicado: (2017)

Helicobacter pylori cagA gene variants in Malaysians of different ethnicity
por: Mohamed, Ramelah, et al.
Publicado: (2009)

Integrin but not CEACAM receptors are dispensable for Helicobacter pylori CagA translocation
por: Zhao, Qing, et al.
Publicado: (2018)

Evolutionary mechanism leading to the multi-cagA genotype in Helicobacter pylori
por: Su, Hanfu, et al.
Publicado: (2019)

Influence of Dietary Factors on Helicobacter pylori and CagA Seroprevalence in Bulgaria
por: Yordanov, Daniel, et al.
Publicado: (2017)

Construction, Cloning, and Expression of CagA Recombinant Protein of Helicobacter pylori
por: Shapouri Moghaddam, Abbas, et al.
Publicado: (2020)

An RGD Helper Sequence in CagL of Helicobacter pylori Assists in Interactions with Integrins and Injection of CagA
por: Conradi, Jens, et al.
Publicado: (2012)

Helicobacter pylori Infection in Thailand: A Nationwide Study of the CagA Phenotype
por: Uchida, Tomohisa, et al.
Publicado: (2015)

Helicobacter pylori cagA and vacA genes in dyspeptic Ghanaian patients
por: Archampong, Timothy N., et al.
Publicado: (2017)

Serum VEGF Levels in Helicobacter pylori Infection and Correlation with Helicobacter pylori cagA and vacA Genes
por: Siregar, Gontar, et al.
Publicado: (2017)

Helicobacter pylori vacA genotype is a predominant determinant of immune response to Helicobacter pylori CagA
por: Link, Alexander, et al.
Publicado: (2017)

Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase α, is crucial for CagA phosphorylation in human duodenum carcinoma cell line AZ-521
por: Nakano, Masayuki, et al.
Publicado: (2016)

Helicobacter pylori CagA promotes epithelial mesenchymal transition in gastric carcinogenesis via triggering oncogenic YAP pathway
por: Li, Nianshuang, et al.
Publicado: (2018)

The H. pylori CagA Oncoprotein Induces DNA Double Strand Breaks through Fanconi Anemia Pathway Downregulation and Replication Fork Collapse
por: Kolinjivadi, Arun Mouli, et al.
Publicado: (2022)

Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori
por: Backert, Steffen, et al.
Publicado: (2011)

Helicobacter pylori CagA Disrupts Epithelial Patterning by Activating Myosin Light Chain
por: Muyskens, Jonathan B., et al.
Publicado: (2011)

Inhibitory Effects of Anthocyanins on Secretion of Helicobacter pylori CagA and VacA Toxins
por: Kim, Sa-Hyun, et al.
Publicado: (2012)

Clinical relevance of the cagA, tnpA and tnpB genes in Helicobacter pylori
por: Abadi, Amin Talebi Bezmin, et al.
Publicado: (2014)

The CagA toxin of Helicobacter pylori: abundant production but relatively low amount translocated
por: Jiménez-Soto, Luisa F., et al.
Publicado: (2016)

Epidemiology of Helicobacter pylori and CagA-Positive Infections and Global Variations in Gastric Cancer
por: Park, Jin Young, et al.
Publicado: (2018)

Prevalence of Helicobacter pylori cagA and iceA Genes and Their Association with Gastrointestinal Diseases
por: Abu-Taleb, Ashwak M. F., et al.
Publicado: (2018)

Western-Type Helicobacter pylori CagA are the Most Frequent Type in Mongolian Patients
por: Tserentogtokh, Tegshee, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_suga2cbd760gnf9284qe9pb34l