Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity

Systemic lupus erythematosus (SLE) is characterized by high-avidity IgG antinuclear antibodies (ANAs) that are almost certainly products of T cell–dependent immune responses. Whether critical amino acids in the third complementarity-determining region (CDR3) of the ANA originate from V(D)J recombina...

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Detalles Bibliográficos
Autores principales: Guo, Wenzhong, Smith, Diana, Aviszus, Katja, Detanico, Thiago, Heiser, Ryan A., Wysocki, Lawrence J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947070/
https://www.ncbi.nlm.nih.gov/pubmed/20805563
http://dx.doi.org/10.1084/jem.20092712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947070/
https://www.ncbi.nlm.nih.gov/pubmed/20805563
http://dx.doi.org/10.1084/jem.20092712

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