Mutant p53 facilitates somatic cell reprogramming and augments the malignant potential of reprogrammed cells

p53 deficiency enhances the efficiency of somatic cell reprogramming to a pluripotent state. As p53 is usually mutated in human tumors and many mutated forms of p53 gain novel activities, we studied the influence of mutant p53 (mut-p53) on somatic cell reprogramming. Our data indicate a novel gain o...

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Detalles Bibliográficos
Autores principales: Sarig, Rachel, Rivlin, Noa, Brosh, Ran, Bornstein, Chamutal, Kamer, Iris, Ezra, Osnat, Molchadsky, Alina, Goldfinger, Naomi, Brenner, Ori, Rotter, Varda
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947075/
https://www.ncbi.nlm.nih.gov/pubmed/20696700
http://dx.doi.org/10.1084/jem.20100797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947075/
https://www.ncbi.nlm.nih.gov/pubmed/20696700
http://dx.doi.org/10.1084/jem.20100797

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