Cargando…

Mutant p53 facilitates somatic cell reprogramming and augments the malignant potential of reprogrammed cells

p53 deficiency enhances the efficiency of somatic cell reprogramming to a pluripotent state. As p53 is usually mutated in human tumors and many mutated forms of p53 gain novel activities, we studied the influence of mutant p53 (mut-p53) on somatic cell reprogramming. Our data indicate a novel gain o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sarig, Rachel, Rivlin, Noa, Brosh, Ran, Bornstein, Chamutal, Kamer, Iris, Ezra, Osnat, Molchadsky, Alina, Goldfinger, Naomi, Brenner, Ori, Rotter, Varda
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947075/ https://www.ncbi.nlm.nih.gov/pubmed/20696700 http://dx.doi.org/10.1084/jem.20100797

Ejemplares similares

p53, a novel regulator of lipid metabolism pathways
por: Goldstein, Ido, et al.
Publicado: (2012)

p53 Plays a Role in Mesenchymal Differentiation Programs, in a Cell Fate Dependent Manner
por: Molchadsky, Alina, et al.
Publicado: (2008)

Various stress stimuli rewire the profile of liver secretome in a p53-dependent manner
por: Charni-Natan, Meital, et al.
Publicado: (2018)

Modulated expression of WFDC1 during carcinogenesis and cellular senescence
por: Madar, Shalom, et al.
Publicado: (2009)

Organelle remodeling in somatic cell reprogramming
por: Liu, Yang, et al.
Publicado: (2020)

p53 on the crossroad between regeneration and cancer
por: Charni, Meital, et al.
Publicado: (2017)

Five Classic Articles in Somatic Cell Reprogramming
por: Park, In-Hyun
Publicado: (2010)

JAK-STAT3 and somatic cell reprogramming
por: Tang, Yong, et al.
Publicado: (2013)

Somatic Reprogramming—Above and Beyond Pluripotency
por: Meir, Yaa-Jyuhn James, et al.
Publicado: (2021)

A Cell Electrofusion Chip for Somatic Cells Reprogramming
por: Wu, Wei, et al.
Publicado: (2015)

Proliferation Rate of Somatic Cells Affects Reprogramming Efficiency
por: Xu, Yongyu, et al.
Publicado: (2013)

Optimal Ratio of Transcription Factors for Somatic Cell Reprogramming
por: Nagamatsu, Go, et al.
Publicado: (2012)

Transcriptome Signature and Regulation in Human Somatic Cell Reprogramming
por: Tanaka, Yoshiaki, et al.
Publicado: (2015)

Conserved regulation of RNA processing in somatic cell reprogramming
por: Kanitz, Alexander, et al.
Publicado: (2019)

Mitochondrial Akt Signaling Modulated Reprogramming of Somatic Cells
por: Chen, Yu-Han, et al.
Publicado: (2019)

Mechanisms of the Metabolic Shift during Somatic Cell Reprogramming
por: Nishimura, Ken, et al.
Publicado: (2019)

Transcriptional defects and reprogramming barriers in somatic cell nuclear reprogramming as revealed by single-embryo RNA sequencing
por: Liu, Yong, et al.
Publicado: (2018)

Identification of Spectral Modifications Occurring during Reprogramming of Somatic Cells
por: Sandt, Christophe, et al.
Publicado: (2012)

microRNAs become macro players in somatic cell reprogramming
por: Onder, Tamer T, et al.
Publicado: (2011)

Reprogramming to Pluripotency Can Conceal Somatic Cell Chromosomal Instability
por: Hamada, Masakazu, et al.
Publicado: (2012)

‘mi’-nimal interference: Somatic cell reprogramming in cancer and therapy
por: Doran, Graeme
Publicado: (2009)

A Stochastic Model of Epigenetic Dynamics in Somatic Cell Reprogramming
por: Flöttmann, Max, et al.
Publicado: (2012)

Looking into the Black Box: Insights into the Mechanisms of Somatic Cell Reprogramming
por: David, Laurent, et al.
Publicado: (2011)

Reprogramming to Pluripotency through a Somatic Stem Cell Intermediate
por: Marthaler, Adele G., et al.
Publicado: (2013)

Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance
por: Ozmadenci, Duygu, et al.
Publicado: (2015)

Somatic cell reprogramming-free generation of genetically modified pigs
por: Tanihara, Fuminori, et al.
Publicado: (2016)

Suppression of the ERK–SRF axis facilitates somatic cell reprogramming
por: Huh, Sejong, et al.
Publicado: (2018)

Generation of induced cardiac progenitor cells via somatic reprogramming
por: Xu, Jianyong, et al.
Publicado: (2017)

Epigenetic Reprogramming of Somatic Genomes by Electrofusion With Embryonic Stem Cells
por: Tada, Masako, et al.
Publicado: (2006)

Label-Free Imaging to Track Reprogramming of Human Somatic Cells
por: Molugu, Kaivalya, et al.
Publicado: (2022)

Transient Acquisition of Pluripotency During Somatic Cell Transdifferentiation with iPSC Reprogramming Factors
por: Maza, Itay, et al.
Publicado: (2015)

TMPRSS2/ERG Promotes Epithelial to Mesenchymal Transition through the ZEB1/ZEB2 Axis in a Prostate Cancer Model
por: Leshem, Orit, et al.
Publicado: (2011)

Dynamically reorganized chromatin is the key for the reprogramming of somatic cells to pluripotent cells
por: Huang, Kaimeng, et al.
Publicado: (2015)

Nuclear reprogramming of sperm and somatic nuclei in eggs and oocytes
por: Teperek, Marta, et al.
Publicado: (2013)

Differential regulated microRNA by wild type and mutant p53 in induced pluripotent stem cells
por: Grespi, Francesca, et al.
Publicado: (2016)

Regulation of somatic cell reprogramming through inducible mir-302 expression
por: Lin, Shi-Lung, et al.
Publicado: (2011)

Linking the p53 tumor suppressor pathway to somatic cell reprogramming
por: Kawamura, Teruhisa, et al.
Publicado: (2009)

In vivo Reprogramming of Adult Somatic Cells to Pluripotency by Overexpression of Yamanaka Factors
por: Yilmazer, Açelya, et al.
Publicado: (2013)

Stress-mediated p38 activation promotes somatic cell reprogramming
por: Xu, Xinxiu, et al.
Publicado: (2013)

NANOG Is Required for the Long-Term Establishment of Avian Somatic Reprogrammed Cells
por: Fuet, Aurélie, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3k160t5fgu9285rci71ch2hbk8