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Addiction-like reward dysfunction and compulsive eating in obese rats: Role for dopamine D2 receptors

We found that development of obesity was coupled with the emergence of a progressively worsening brain reward deficit. Similar changes in reward homeostasis induced by cocaine or heroin is considered a critical trigger in the transition from casual to compulsive drug-taking. Accordingly, we detected...

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Detalles Bibliográficos
Autores principales: Johnson, Paul M., Kenny, Paul J.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947358/
https://www.ncbi.nlm.nih.gov/pubmed/20348917
http://dx.doi.org/10.1038/nn.2519