Application of statistical and functional methodologies for the investigation of genetic determinants of coronary heart disease biomarkers: lipoprotein lipase genotype and plasma triglycerides as an exemplar

Genome-wide association studies have proved very successful in identifying novel single-nucleotide polymorphisms (SNPs) associated with disease or traits, but the related, functional SNP is usually unknown. In this paper, we describe a methodology to locate and validate candidate functional SNPs usi...

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Detalles Bibliográficos
Autores principales: Smith, Andrew J.P., Palmen, Jutta, Putt, Wendy, Talmud, Philippa J., Humphries, Steve E., Drenos, Fotios
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947402/
https://www.ncbi.nlm.nih.gov/pubmed/20650961
http://dx.doi.org/10.1093/hmg/ddq308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947402/
https://www.ncbi.nlm.nih.gov/pubmed/20650961
http://dx.doi.org/10.1093/hmg/ddq308

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