Sprouty Proteins Inhibit Receptor-mediated Activation of Phosphatidylinositol-specific Phospholipase C

Sprouty (Spry) proteins are negative regulators of receptor tyrosine kinase signaling; however, their exact mechanism of action remains incompletely understood. We identified phosphatidylinositol-specific phospholipase C (PLC)-γ as a partner of the Spry1 and Spry2 proteins. Spry–PLCγ interaction was...

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Detalles Bibliográficos
Autores principales: Akbulut, Simge, Reddi, Alagarsamy L., Aggarwal, Priya, Ambardekar, Charuta, Canciani, Barbara, Kim, Marianne K.H., Hix, Laura, Vilimas, Tomas, Mason, Jacqueline, Basson, M. Albert, Lovatt, Matthew, Powell, Jonathan, Collins, Samuel, Quatela, Steven, Phillips, Mark, Licht, Jonathan D.
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947483/
https://www.ncbi.nlm.nih.gov/pubmed/20719962
http://dx.doi.org/10.1091/mbc.E10-02-0123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947483/
https://www.ncbi.nlm.nih.gov/pubmed/20719962
http://dx.doi.org/10.1091/mbc.E10-02-0123

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