Targeting the PI3K/Akt Cell Survival Pathway to Induce Cell Death of HIV-1 Infected Macrophages with Alkylphospholipid Compounds

BACKGROUND: HIV-1 infected macrophages and microglia are long-lived viral reservoirs persistently producing viral progenies. HIV-1 infection extends the life span of macrophages by promoting the stress-induced activation of the PI3K/Akt cell survival pathway. Importantly, various cancers also displa...

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Detalles Bibliográficos
Autores principales: Lucas, Amanda, Kim, Yuri, Rivera-Pabon, Omayra, Chae, Sunju, Kim, Dong-Hyun, Kim, Baek
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948033/
https://www.ncbi.nlm.nih.gov/pubmed/20927348
http://dx.doi.org/10.1371/journal.pone.0013121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948033/
https://www.ncbi.nlm.nih.gov/pubmed/20927348
http://dx.doi.org/10.1371/journal.pone.0013121

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