Cargando…

Targeting the PI3K/Akt Cell Survival Pathway to Induce Cell Death of HIV-1 Infected Macrophages with Alkylphospholipid Compounds

BACKGROUND: HIV-1 infected macrophages and microglia are long-lived viral reservoirs persistently producing viral progenies. HIV-1 infection extends the life span of macrophages by promoting the stress-induced activation of the PI3K/Akt cell survival pathway. Importantly, various cancers also displa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lucas, Amanda, Kim, Yuri, Rivera-Pabon, Omayra, Chae, Sunju, Kim, Dong-Hyun, Kim, Baek
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948033/ https://www.ncbi.nlm.nih.gov/pubmed/20927348 http://dx.doi.org/10.1371/journal.pone.0013121

Ejemplares similares

Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids
por: Jiménez-López, José M, et al.
Publicado: (2010)

The alkylphospholipid, perifosine, radiosensitizes prostate cancer cells both in vitro and in vivo
por: Gao, Yuanhong, et al.
Publicado: (2011)

In Vitro and In Vivo Anti-Schistosomal Activity of the Alkylphospholipid Analog Edelfosine
por: Yepes, Edward, et al.
Publicado: (2014)

Endoplasmic reticulum targeting in Ewing's sarcoma by the alkylphospholipid analog edelfosine
por: Bonilla, Ximena, et al.
Publicado: (2015)

Correction: In Vitro and In Vivo Anti-Schistosomal Activity of the Alkylphospholipid Analog Edelfosine
Publicado: (2015)

Dual Gene Delivery Reagents From Antiproliferative Alkylphospholipids for Combined Antitumor Therapy
por: Gaillard, Boris, et al.
Publicado: (2020)

In Vitro Study of Cytotoxic Mechanisms of Alkylphospholipids and Alkyltriazoles in Acute Lymphoblastic Leukemia Models
por: Jesus, Larissa de Oliveira Passos, et al.
Publicado: (2022)

Perifosine, a Bioavailable Alkylphospholipid Akt Inhibitor, Exhibits Antitumor Activity in Murine Models of Cancer Brain Metastasis Through Favorable Tumor Exposure
por: Taniguchi, Keisuke, et al.
Publicado: (2021)

Novel PI3K/Akt Inhibitors Screened by the Cytoprotective Function of Human Immunodeficiency Virus Type 1 Tat
por: Kim, Yuri, et al.
Publicado: (2011)

Induction of Apoptosis in Human Pancreatic Cancer Stem Cells by the Endoplasmic Reticulum-Targeted Alkylphospholipid Analog Edelfosine and Potentiation by Autophagy Inhibition
por: Gajate, Consuelo, et al.
Publicado: (2021)

Mitochondrial Targeting Involving Cholesterol-Rich Lipid Rafts in the Mechanism of Action of the Antitumor Ether Lipid and Alkylphospholipid Analog Edelfosine
por: Mollinedo, Faustino, et al.
Publicado: (2021)

Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia
por: Ecker, Veronika, et al.
Publicado: (2021)

Selaginella tamariscina Inhibits Glutamate-Induced Autophagic Cell Death by Activating the PI3K/AKT/mTOR Signaling Pathways
por: Jeong, Yun Hee, et al.
Publicado: (2022)

Role of PI3K/Akt signaling in memory CD8 T cell differentiation
por: Kim, Eui Ho, et al.
Publicado: (2013)

Melatonin Combined with Endoplasmic Reticulum Stress Induces Cell Death via the PI3K/Akt/mTOR Pathway in B16F10 Melanoma Cells
por: Kim, Han Sung, et al.
Publicado: (2014)

Direct Endoplasmic Reticulum Targeting by the Selective Alkylphospholipid Analog and Antitumor Ether Lipid Edelfosine as a Therapeutic Approach in Pancreatic Cancer
por: Mollinedo, Faustino, et al.
Publicado: (2021)

AKT1-targeted proapoptotic activity of compound K in human breast cancer cells
por: Choi, Eunju, et al.
Publicado: (2019)

Swimming prevents cell death of chondrocytes via PI3K/AKT pathway in an experimental model
por: Qian, Jiajia, et al.
Publicado: (2023)

Iridin Induces G2/M Phase Cell Cycle Arrest and Extrinsic Apoptotic Cell Death through PI3K/AKT Signaling Pathway in AGS Gastric Cancer Cells
por: Bhosale, Pritam-Bhagwan, et al.
Publicado: (2021)

Compound K, a ginsenoside metabolite, plays an antiinflammatory role in macrophages by targeting the AKT1-mediated signaling pathway
por: Lee, Jeong-Oog, et al.
Publicado: (2019)

Docosahexaenoic Acid Induces Cell Death in Human Non-Small Cell Lung Cancer Cells by Repressing mTOR via AMPK Activation and PI3K/Akt Inhibition
por: Kim, Nayeong, et al.
Publicado: (2015)

Compound Kushen injection inhibits EMT of gastric cancer cells via the PI3K/AKT pathway
por: Li, Luo, et al.
Publicado: (2022)

Gomisin N Inhibits Melanogenesis through Regulating the PI3K/Akt and MAPK/ERK Signaling Pathways in Melanocytes
por: Chae, Jae Kyoung, et al.
Publicado: (2017)

HOXA5 confers tamoxifen resistance via the PI3K/AKT signaling pathway in ER-positive breast cancer
por: Kim, Clara Yuri, et al.
Publicado: (2021)

EGFR Activation Leads to Cell Death Independent of PI3K/AKT/mTOR in an AD293 Cell Line
por: Treda, Cezary, et al.
Publicado: (2016)

Lupenone Protects Neuroblastoma SH-SY5y Cells Against Methamphetamine-Induced Apoptotic Cell Death via PI3K/Akt/mTOR Signaling Pathway
por: Lee, Hyun-Su, et al.
Publicado: (2020)

Induction of apoptotic cell death in human bladder cancer cells by ethanol extract of Zanthoxylum schinifolium leaf, through ROS-dependent inactivation of the PI3K/Akt signaling pathway
por: Park, Cheol, et al.
Publicado: (2022)

Treadmill exercise reduces spinal cord injury-induced apoptosis by activating the PI3K/Akt pathway in rats
por: JUNG, SUN-YOUNG, et al.
Publicado: (2014)

Myricetin Inhibits Angiogenesis by Inducing Apoptosis and Suppressing PI3K/Akt/mTOR Signaling in Endothelial Cells
por: Kim, Gi Dae
Publicado: (2017)

Anti-Inflammatory Activity of Extracts and Pure Compounds Derived from Plants via Modulation of Signaling Pathways, Especially PI3K/AKT in Macrophages
por: Merecz-Sadowska, Anna, et al.
Publicado: (2020)

M2 macrophages, but not M1 macrophages, support megakaryopoiesis by upregulating PI3K-AKT pathway activity
por: Zhao, Hong-Yan, et al.
Publicado: (2021)

Dual Inhibition of PI3K/Akt/mTOR Pathway and Role of Autophagy in Non-Small Cell Lung Cancer Cells
por: Jeong, Eun-Hui, et al.
Publicado: (2012)

Fibronectin expression is upregulated by PI-3K/Akt activation in tamoxifen-resistant breast cancer cells
por: You, Daeun, et al.
Publicado: (2017)

PI3K–AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic Compounds
por: Yuan, Yeqin, et al.
Publicado: (2023)

Ginsenoside compound K inhibits the proliferation, migration and invasion of Eca109 cell via VEGF-A/Pi3k/Akt pathway
por: Huang, Jianhou, et al.
Publicado: (2022)

Crocin induces autophagic cell death and inhibits cell invasion of cervical cancer SiHa cells through activation of PI3K/AKT
por: Zhang, Jian, et al.
Publicado: (2020)

Activation of the PI3K/AKT Pathway in Merkel Cell Carcinoma
por: Hafner, Christian, et al.
Publicado: (2012)

Cabazitaxel-induced autophagy via the PI3K/Akt/mTOR pathway contributes to A549 cell death
por: Huo, Ruichao, et al.
Publicado: (2016)

Chrysophanol-Induced Autophagy Disrupts Apoptosis via the PI3K/Akt/mTOR Pathway in Oral Squamous Cell Carcinoma Cells
por: Park, Dan-Bi, et al.
Publicado: (2022)

Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway
por: Deng, Q, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_t822n56ltvlnpdffvo92ombdsl