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Epigenetic regulation of antigen receptor gene rearrangement

V(D)J recombination assembles antigen-specific immunoglobulin and T-cell receptor variable region genes from germline V, D, and J segments during lymphocyte development. Regulation of this site-specific DNA rearrangement process occurs with respect to the cell type and stage of differentiation, orde...

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Autores principales: Spicuglia, Salvatore, Zacarias-Cabeza, Joaquin, Pekowska, Aleksandra, Ferrier, Pierre
Formato: Texto
Lenguaje:English
Publicado: Faculty of 1000 Ltd 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948343/
https://www.ncbi.nlm.nih.gov/pubmed/20948810
http://dx.doi.org/10.3410/B2-23
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author Spicuglia, Salvatore
Zacarias-Cabeza, Joaquin
Pekowska, Aleksandra
Ferrier, Pierre
author_facet Spicuglia, Salvatore
Zacarias-Cabeza, Joaquin
Pekowska, Aleksandra
Ferrier, Pierre
author_sort Spicuglia, Salvatore
collection PubMed
description V(D)J recombination assembles antigen-specific immunoglobulin and T-cell receptor variable region genes from germline V, D, and J segments during lymphocyte development. Regulation of this site-specific DNA rearrangement process occurs with respect to the cell type and stage of differentiation, order of locus recombination, and allele usage. Many of these controls are mediated via the modulation of gene accessibility to the V(D)J recombinase. Here, we summarise recent advances regarding the impact of nuclear organisation and epigenetic-based mechanisms on the regulation of V(D)J recombination.
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spelling pubmed-29483432010-10-14 Epigenetic regulation of antigen receptor gene rearrangement Spicuglia, Salvatore Zacarias-Cabeza, Joaquin Pekowska, Aleksandra Ferrier, Pierre F1000 Biol Rep Review Article V(D)J recombination assembles antigen-specific immunoglobulin and T-cell receptor variable region genes from germline V, D, and J segments during lymphocyte development. Regulation of this site-specific DNA rearrangement process occurs with respect to the cell type and stage of differentiation, order of locus recombination, and allele usage. Many of these controls are mediated via the modulation of gene accessibility to the V(D)J recombinase. Here, we summarise recent advances regarding the impact of nuclear organisation and epigenetic-based mechanisms on the regulation of V(D)J recombination. Faculty of 1000 Ltd 2010-03-25 /pmc/articles/PMC2948343/ /pubmed/20948810 http://dx.doi.org/10.3410/B2-23 Text en © 2010 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Spicuglia, Salvatore
Zacarias-Cabeza, Joaquin
Pekowska, Aleksandra
Ferrier, Pierre
Epigenetic regulation of antigen receptor gene rearrangement
title Epigenetic regulation of antigen receptor gene rearrangement
title_full Epigenetic regulation of antigen receptor gene rearrangement
title_fullStr Epigenetic regulation of antigen receptor gene rearrangement
title_full_unstemmed Epigenetic regulation of antigen receptor gene rearrangement
title_short Epigenetic regulation of antigen receptor gene rearrangement
title_sort epigenetic regulation of antigen receptor gene rearrangement
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948343/
https://www.ncbi.nlm.nih.gov/pubmed/20948810
http://dx.doi.org/10.3410/B2-23
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