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Epigenetic regulation of antigen receptor gene rearrangement
V(D)J recombination assembles antigen-specific immunoglobulin and T-cell receptor variable region genes from germline V, D, and J segments during lymphocyte development. Regulation of this site-specific DNA rearrangement process occurs with respect to the cell type and stage of differentiation, orde...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Faculty of 1000 Ltd
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948343/ https://www.ncbi.nlm.nih.gov/pubmed/20948810 http://dx.doi.org/10.3410/B2-23 |
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author | Spicuglia, Salvatore Zacarias-Cabeza, Joaquin Pekowska, Aleksandra Ferrier, Pierre |
author_facet | Spicuglia, Salvatore Zacarias-Cabeza, Joaquin Pekowska, Aleksandra Ferrier, Pierre |
author_sort | Spicuglia, Salvatore |
collection | PubMed |
description | V(D)J recombination assembles antigen-specific immunoglobulin and T-cell receptor variable region genes from germline V, D, and J segments during lymphocyte development. Regulation of this site-specific DNA rearrangement process occurs with respect to the cell type and stage of differentiation, order of locus recombination, and allele usage. Many of these controls are mediated via the modulation of gene accessibility to the V(D)J recombinase. Here, we summarise recent advances regarding the impact of nuclear organisation and epigenetic-based mechanisms on the regulation of V(D)J recombination. |
format | Text |
id | pubmed-2948343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Faculty of 1000 Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-29483432010-10-14 Epigenetic regulation of antigen receptor gene rearrangement Spicuglia, Salvatore Zacarias-Cabeza, Joaquin Pekowska, Aleksandra Ferrier, Pierre F1000 Biol Rep Review Article V(D)J recombination assembles antigen-specific immunoglobulin and T-cell receptor variable region genes from germline V, D, and J segments during lymphocyte development. Regulation of this site-specific DNA rearrangement process occurs with respect to the cell type and stage of differentiation, order of locus recombination, and allele usage. Many of these controls are mediated via the modulation of gene accessibility to the V(D)J recombinase. Here, we summarise recent advances regarding the impact of nuclear organisation and epigenetic-based mechanisms on the regulation of V(D)J recombination. Faculty of 1000 Ltd 2010-03-25 /pmc/articles/PMC2948343/ /pubmed/20948810 http://dx.doi.org/10.3410/B2-23 Text en © 2010 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes |
spellingShingle | Review Article Spicuglia, Salvatore Zacarias-Cabeza, Joaquin Pekowska, Aleksandra Ferrier, Pierre Epigenetic regulation of antigen receptor gene rearrangement |
title | Epigenetic regulation of antigen receptor gene rearrangement |
title_full | Epigenetic regulation of antigen receptor gene rearrangement |
title_fullStr | Epigenetic regulation of antigen receptor gene rearrangement |
title_full_unstemmed | Epigenetic regulation of antigen receptor gene rearrangement |
title_short | Epigenetic regulation of antigen receptor gene rearrangement |
title_sort | epigenetic regulation of antigen receptor gene rearrangement |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948343/ https://www.ncbi.nlm.nih.gov/pubmed/20948810 http://dx.doi.org/10.3410/B2-23 |
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