Cargando…
l-Arginine deprivation impairs Leishmania major-specific T-cell responses
The amino acid l-arginine plays a crucial role in the regulation of immune responses. We have recently shown that uncontrolled replication of Leishmania parasites at the site of pathology correlates with high levels of arginase activity in nonhealing leishmaniasis and that this elevated arginase act...
Autores principales: | Munder, Markus, Choi, Beak-San, Rogers, Matthew, Kropf, Pascale |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
WILEY-VCH Verlag
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948424/ https://www.ncbi.nlm.nih.gov/pubmed/19637195 http://dx.doi.org/10.1002/eji.200839041 |
Ejemplares similares
-
Proteophosophoglycans Regurgitated by Leishmania-Infected Sand Flies Target the L-Arginine Metabolism of Host Macrophages to Promote Parasite Survival
por: Rogers, Matthew, et al.
Publicado: (2009) -
Batf3-dependent CD103(+) dendritic cells are major producers of IL-12 that drive local Th1 immunity against Leishmania major infection in mice
por: Martínez-López, María, et al.
Publicado: (2015) -
Local Suppression of T Cell Responses by Arginase-Induced L-Arginine Depletion in Nonhealing Leishmaniasis
por: Modolell, Manuel, et al.
Publicado: (2009) -
Arginase activity mediates reversible T cell hyporesponsiveness in human pregnancy
por: Kropf, Pascale, et al.
Publicado: (2007) -
Differential impact of l-arginine deprivation on the activation and effector functions of T cells and macrophages
por: Choi, B.-S., et al.
Publicado: (2009)