Monomerization of Cytosolic Mature Smac Attenuates Interaction with IAPs and Potentiation of Caspase Activation

The four residues at the amino-terminus of mature Smac/DIABLO are an IAP binding motif (IBM). Upon exit from mitochondria, mature Smac interacts with inhibitor of apoptosis proteins (IAPs), abrogating caspase inhibition. We used the ubiquitin fusion model to express mature Smac in the cytosol. Trans...

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Detalles Bibliográficos
Autores principales: Burke, Stephen P., Smith, Jeffrey B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948501/
https://www.ncbi.nlm.nih.gov/pubmed/20957035
http://dx.doi.org/10.1371/journal.pone.0013094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948501/
https://www.ncbi.nlm.nih.gov/pubmed/20957035
http://dx.doi.org/10.1371/journal.pone.0013094

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