Checkpoint Dependent Inhibition of DNA Replication Initiation by Sld3 and Dbf4 Phosphorylation

The initiation of eukaryotic DNA replication is regulated by three protein kinase classes: cyclin dependent kinases (CDK), Dbf4-dependent kinase (DDK) and the DNA damage checkpoint kinases1. CDK phosphorylation of two key initiation factors, Sld2 and Sld3, promotes essential interactions with Dpb112...

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Detalles Bibliográficos
Autores principales: Zegerman, Philip, Diffley, John F. X.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948544/
https://www.ncbi.nlm.nih.gov/pubmed/20835227
http://dx.doi.org/10.1038/nature09373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948544/
https://www.ncbi.nlm.nih.gov/pubmed/20835227
http://dx.doi.org/10.1038/nature09373

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