Elevated Levels of DNA Strand Breaks Induced by a Base Analog in the Human Cell Line with the P32T ITPA Variant

Base analogs are powerful antimetabolites and dangerous mutagens generated endogenously by oxidative stress, inflammation, and aberrant nucleotide biosynthesis. Human inosine triphosphate pyrophosphatase (ITPA) hydrolyzes triphosphates of noncanonical purine bases (i.e., ITP, dITP, XTP, dXTP, or the...

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Detalles Bibliográficos
Autores principales: Waisertreiger, Irina S.-R., Menezes, Miriam R., Randazzo, James, Pavlov, Youri I.
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948936/
https://www.ncbi.nlm.nih.gov/pubmed/20936128
http://dx.doi.org/10.4061/2010/872180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948936/
https://www.ncbi.nlm.nih.gov/pubmed/20936128
http://dx.doi.org/10.4061/2010/872180

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