Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity

Strategies to combat HIV-1 require structural knowledge of envelope proteins from clade C viruses, the most common in the world. We present the first crystal structure containing a clade C gp120 envelope. The structure, a complex between gp120, the host receptor CD4, and the CD4-induced antibody 21c...

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Detalles Bibliográficos
Autores principales: Diskin, Ron, Marcovecchio, Paola M., Bjorkman, Pamela J.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949298/
https://www.ncbi.nlm.nih.gov/pubmed/20357769
http://dx.doi.org/10.1038/nsmb.1796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949298/
https://www.ncbi.nlm.nih.gov/pubmed/20357769
http://dx.doi.org/10.1038/nsmb.1796

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