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Preclinical Evaluation of Novel Triphenylphosphonium Salts with Broad-Spectrum Activity

BACKGROUND: Recently, there has been a surge of interest in developing compounds selectively targeting mitochondria for the treatment of neoplasms. The critical role of mitochondria in cellular metabolism and respiration supports this therapeutic rationale. Dysfunction in the processes of energy pro...

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Detalles Bibliográficos
Autores principales: Millard, Melissa, Pathania, Divya, Shabaik, Yumna, Taheri, Laleh, Deng, Jinxia, Neamati, Nouri
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949386/
https://www.ncbi.nlm.nih.gov/pubmed/20957228
http://dx.doi.org/10.1371/journal.pone.0013131