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The WTX/AMER1 gene family: evolution, signature and function

BACKGROUND: WTX is a novel gene mutated in a proportion of Wilms' tumors and in patients suffering from sclerosing bone dysplasia. On the molecular level WTX has been shown to act as an antagonist of canonical Wnt/β-catenin signaling in fish and mammals thus linking it to an essential pathway i...

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Detalles Bibliográficos
Autores principales: Boutet, Agnès, Comai, Glenda, Schedl, Andreas
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949870/
https://www.ncbi.nlm.nih.gov/pubmed/20843316
http://dx.doi.org/10.1186/1471-2148-10-280