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Filtering, FDR and power

BACKGROUND: In high-dimensional data analysis such as differential gene expression analysis, people often use filtering methods like fold-change or variance filters in an attempt to reduce the multiple testing penalty and improve power. However, filtering may introduce a bias on the multiple testing...

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Detalles Bibliográficos
Autores principales: van Iterson, Maarten, Boer, Judith M, Menezes, Renée X
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949886/
https://www.ncbi.nlm.nih.gov/pubmed/20822518
http://dx.doi.org/10.1186/1471-2105-11-450