Over-expression of CKS1B activates both MEK/ERK and JAK/STAT3 signaling pathways and promotes myeloma cell drug-resistance

Here we demonstrate the crucial role of CKS1B in multiple myeloma (MM) progression and define CKS1B-mediated SKP2/p27(Kip1)-independent down-stream signaling pathways. Forced-expression of CKS1B in MM cells increased cell multidrug-resistance. CKS1B activates STAT3 and MEK/ERK pathways. In contrast,...

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Detalles Bibliográficos
Autores principales: Shi, Lei, Wang, Siqing, Zangari, Maurizio, Xu, Hongwei, Cao, Thai M., Xu, Chunjiao, Wu, Yong, Xiao, Fang, Liu, Yinghong, Yang, Ye, Salama, Mohamed, Li, Guiyuan, Tricot, Guido, Zhan, Fenghuang
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949973/
https://www.ncbi.nlm.nih.gov/pubmed/20930946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949973/
https://www.ncbi.nlm.nih.gov/pubmed/20930946

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