Prion Replication in the Hematopoietic Compartment Is Not Required for Neuroinvasion in Scrapie Mouse Model

Fatal neurodegenerative prion diseases are caused by the transmissible PrP(Sc) prion agent whose initial replication after peripheral inoculation takes place in follicular dendritic cells present in germinal centers of lymphoid organs. However, prion replication also occurs in lymphoid cells. To ass...

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Detalles Bibliográficos
Autores principales: Loeuillet, Corinne, Lemaire-Vieille, Catherine, Naquet, Philippe, Cesbron-Delauw, Marie-France, Gagnon, Jean, Cesbron, Jean-Yves
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950141/
https://www.ncbi.nlm.nih.gov/pubmed/20957200
http://dx.doi.org/10.1371/journal.pone.0013166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950141/
https://www.ncbi.nlm.nih.gov/pubmed/20957200
http://dx.doi.org/10.1371/journal.pone.0013166

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