In vitro and in vivo effects of polyethylene glycol (PEG)-modified lipid in DOTAP/cholesterol-mediated gene transfection

BACKGROUND: DOTAP/cholesterol-based lipoplexes are successfully used for delivery of plasmid DNA in vivo especially to the lungs, although low systemic stability and circulation have been reported. To achieve the aim of discovering the best method for systemic delivery of DNA to disseminated tumors...

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Detalles Bibliográficos
Autores principales: Gjetting, Torben, Arildsen, Nicolai Skovbjerg, Christensen, Camilla Laulund, Poulsen, Thomas Tuxen, Roth, Jack A, Handlos, Vagn Neerup, Poulsen, Hans Skovgaard
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950395/
https://www.ncbi.nlm.nih.gov/pubmed/20957159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950395/
https://www.ncbi.nlm.nih.gov/pubmed/20957159

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