Drug Off-Target Effects Predicted Using Structural Analysis in the Context of a Metabolic Network Model

Recent advances in structural bioinformatics have enabled the prediction of protein-drug off-targets based on their ligand binding sites. Concurrent developments in systems biology allow for prediction of the functional effects of system perturbations using large-scale network models. Integration of...

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Detalles Bibliográficos
Autores principales: Chang, Roger L., Xie, Li, Xie, Lei, Bourne, Philip E., Palsson, Bernhard Ø.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950675/
https://www.ncbi.nlm.nih.gov/pubmed/20957118
http://dx.doi.org/10.1371/journal.pcbi.1000938

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950675/
https://www.ncbi.nlm.nih.gov/pubmed/20957118
http://dx.doi.org/10.1371/journal.pcbi.1000938

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