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Drug Off-Target Effects Predicted Using Structural Analysis in the Context of a Metabolic Network Model
Recent advances in structural bioinformatics have enabled the prediction of protein-drug off-targets based on their ligand binding sites. Concurrent developments in systems biology allow for prediction of the functional effects of system perturbations using large-scale network models. Integration of...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950675/ https://www.ncbi.nlm.nih.gov/pubmed/20957118 http://dx.doi.org/10.1371/journal.pcbi.1000938 |