Modelling the Role of UCH-L1 on Protein Aggregation in Age-Related Neurodegeneration

Overexpression of the de-ubiquitinating enzyme UCH-L1 leads to inclusion formation in response to proteasome impairment. These inclusions contain components of the ubiquitin-proteasome system and α-synuclein confirming that the ubiquitin-proteasome system plays an important role in protein aggregati...

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Detalles Bibliográficos
Autores principales: Proctor, Carole J., Tangeman, Paul J., Ardley, Helen C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950841/
https://www.ncbi.nlm.nih.gov/pubmed/20949132
http://dx.doi.org/10.1371/journal.pone.0013175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950841/
https://www.ncbi.nlm.nih.gov/pubmed/20949132
http://dx.doi.org/10.1371/journal.pone.0013175

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