Discovery of Small Molecule Inhibitors of the PH Domain Leucine-Rich Repeat Protein Phosphatase (PHLPP) by Chemical and Virtual Screening

[Image: see text] PH domain Leucine-rich repeat protein phosphatase (PHLPP) directly dephosphorylates and inactivates Akt and protein kinase C, poising it as a prime target for pharmacological intervention of two major survival pathways. Here we report on the discovery of small molecule inhibitors o...

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Detalles Bibliográficos
Autores principales: Sierecki, Emma, Sinko, William, McCammon, J. Andrew, Newton, Alexandra C.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2010
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951065/
https://www.ncbi.nlm.nih.gov/pubmed/20836557
http://dx.doi.org/10.1021/jm100331d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951065/
https://www.ncbi.nlm.nih.gov/pubmed/20836557
http://dx.doi.org/10.1021/jm100331d

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