Tumor-supportive and Osteoclastogenic Changes Induced by Breast Cancer-derived Factors Are Reversed by Inhibition of γ-Secretase

During breast cancer metastasis to bone, tumor cells home to bone marrow, likely targeting the stem cell niche, and stimulate osteoclasts, which mediate osteolysis required for tumor expansion. Although osteoblasts contribute to the regulation of the hematopoietic stem cell niche and control osteocl...

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Detalles Bibliográficos
Autores principales: Fong, Jenna E., Le Nihouannen, Damien, Komarova, Svetlana V.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951217/
https://www.ncbi.nlm.nih.gov/pubmed/20679341
http://dx.doi.org/10.1074/jbc.M110.114496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951217/
https://www.ncbi.nlm.nih.gov/pubmed/20679341
http://dx.doi.org/10.1074/jbc.M110.114496

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