Simultaneous Disruption of Two DNA Polymerases, Polη and Polζ, in Avian DT40 Cells Unmasks the Role of Polη in Cellular Response to Various DNA Lesions

Replicative DNA polymerases are frequently stalled by DNA lesions. The resulting replication blockage is released by homologous recombination (HR) and translesion DNA synthesis (TLS). TLS employs specialized TLS polymerases to bypass DNA lesions. We provide striking in vivo evidence of the cooperati...

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Detalles Bibliográficos
Autores principales: Hirota, Kouji, Sonoda, Eiichiro, Kawamoto, Takuo, Motegi, Akira, Masutani, Chikahide, Hanaoka, Fumio, Szüts, Dávid, Iwai, Shigenori, Sale, Julian E., Lehmann, Alan, Takeda, Shunichi
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951353/
https://www.ncbi.nlm.nih.gov/pubmed/20949111
http://dx.doi.org/10.1371/journal.pgen.1001151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951353/
https://www.ncbi.nlm.nih.gov/pubmed/20949111
http://dx.doi.org/10.1371/journal.pgen.1001151

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