Structural Transformation of the Tandem Ubiquitin-Interacting Motifs in Ataxin-3 and Their Cooperative Interactions with Ubiquitin Chains

The ubiquitin-interacting motif (UIM) is a short peptide with dual function of binding ubiquitin (Ub) and promoting ubiquitination. We elucidated the structures and dynamics of the tandem UIMs of ataxin-3 (AT3-UIM12) both in free and Ub-bound forms. The solution structure of free AT3-UIM12 consists...

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Detalles Bibliográficos
Autores principales: Song, Ai-Xin, Zhou, Chen-Jie, Peng, Yu, Gao, Xue-Chao, Zhou, Zi-Ren, Fu, Qing-Shan, Hong, Jing, Lin, Dong-Hai, Hu, Hong-Yu
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951365/
https://www.ncbi.nlm.nih.gov/pubmed/20949063
http://dx.doi.org/10.1371/journal.pone.0013202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951365/
https://www.ncbi.nlm.nih.gov/pubmed/20949063
http://dx.doi.org/10.1371/journal.pone.0013202

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