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Signal Transduction Protein Array Analysis Links LRRK2 to Ste20 Kinases and PKC Zeta That Modulate Neuronal Plasticity

BACKGROUND: Dominant mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, however, the underlying pathogenic mechanisms are poorly understood. Several in vitro studies have shown that the most frequent mutation, LRRK2(G2019S), increases kin...

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Detalles Bibliográficos
Autores principales: Zach, Susanne, Felk, Sandra, Gillardon, Frank
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951910/
https://www.ncbi.nlm.nih.gov/pubmed/20949042
http://dx.doi.org/10.1371/journal.pone.0013191