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Deleterious effects of reactive metabolites

A number of drugs have been withdrawn from the market or severely restricted in their use because of unexpected toxicities that become apparent only after the launch of new drug entities. Circumstantial evidence suggests that, in most cases, reactive metabolites are responsible for these unexpected...

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Detalles Bibliográficos
Autor principal: Attia, Sabry M
Formato: Texto
Lenguaje:English
Publicado: Landes Bioscience 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952084/
https://www.ncbi.nlm.nih.gov/pubmed/20972370
http://dx.doi.org/10.4161/oxim.3.4.13246