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Deleterious effects of reactive metabolites
A number of drugs have been withdrawn from the market or severely restricted in their use because of unexpected toxicities that become apparent only after the launch of new drug entities. Circumstantial evidence suggests that, in most cases, reactive metabolites are responsible for these unexpected...
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| Formato: | Texto |
| Lenguaje: | English |
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Landes Bioscience
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952084/ https://www.ncbi.nlm.nih.gov/pubmed/20972370 http://dx.doi.org/10.4161/oxim.3.4.13246 |