Aberrant Cytoplasm Localization and Protein Stability of SIRT1 is Regulated by PI3K/IGF-1R Signaling in Human Cancer Cells

SIRT1, an NAD-dependent histone/protein deacetylase, has classically been thought of as a nuclear protein. In this study, we demonstrate that SIRT1 is mainly localized in the nucleus of normal cells, but is predominantly localized in the cytoplasm of the cancer / transformed cells we tested. We foun...

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Detalles Bibliográficos
Autores principales: Byles, Vanessa, Chmilewski, Laura K., Wang, Joyce, Zhu, Lijia, Forman, Lora W., Faller, Douglas V., Dai, Yan
Formato: Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2010
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952410/
https://www.ncbi.nlm.nih.gov/pubmed/20941378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952410/
https://www.ncbi.nlm.nih.gov/pubmed/20941378

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