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Retinoic Acid Increases Proliferation of Human Osteoclast Progenitors and Inhibits RANKL-Stimulated Osteoclast Differentiation by Suppressing RANK

It has been shown that high vitamin A intake is associated with bone fragility and fractures in both animals and humans. However, the mechanism by which vitamin A affects bones is unclear. In the present study, the direct effects of retinoic acid (RA) on human and murine osteoclastogenesis were eval...

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Detalles Bibliográficos
Autores principales: Hu, Lijuan, Lind, Thomas, Sundqvist, Anders, Jacobson, Annica, Melhus, Håkan
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952600/
https://www.ncbi.nlm.nih.gov/pubmed/20949013
http://dx.doi.org/10.1371/journal.pone.0013305