Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1

We used mouse hepatic chromatin enriched with an FXR antibody and chromatin immunoprecipitation-sequencing (ChIP-seq) to evaluate FXR binding on a genome-wide scale. This identified 1656 FXR-binding sites and 10% were located within 2 kb of a transcription start site which is much higher than predic...

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Detalles Bibliográficos
Autores principales: Chong, Hansook Kim, Infante, Aniello M., Seo, Young-Kyo, Jeon, Tae-Il, Zhang, Yanqiao, Edwards, Peter A., Xie, Xiaohui, Osborne, Timothy F.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952856/
https://www.ncbi.nlm.nih.gov/pubmed/20483916
http://dx.doi.org/10.1093/nar/gkq397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952856/
https://www.ncbi.nlm.nih.gov/pubmed/20483916
http://dx.doi.org/10.1093/nar/gkq397

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