Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusion

Otoferlin is a large multi–C2 domain protein proposed to act as a calcium sensor that regulates synaptic vesicle exocytosis in cochlear hair cells. Although mutations in otoferlin have been associated with deafness, its contribution to neurotransmitter release is unresolved. Using recombinant protei...

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Detalles Bibliográficos
Autores principales: Johnson, Colin P., Chapman, Edwin R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953437/
https://www.ncbi.nlm.nih.gov/pubmed/20921140
http://dx.doi.org/10.1083/jcb.201002089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953437/
https://www.ncbi.nlm.nih.gov/pubmed/20921140
http://dx.doi.org/10.1083/jcb.201002089

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