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Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusion
Otoferlin is a large multi–C2 domain protein proposed to act as a calcium sensor that regulates synaptic vesicle exocytosis in cochlear hair cells. Although mutations in otoferlin have been associated with deafness, its contribution to neurotransmitter release is unresolved. Using recombinant protei...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953437/ https://www.ncbi.nlm.nih.gov/pubmed/20921140 http://dx.doi.org/10.1083/jcb.201002089 |