Genipin-Induced Inhibition of Uncoupling Protein-2 Sensitizes Drug-Resistant Cancer Cells to Cytotoxic Agents

Uncoupling protein-2 (UCP2) is known to suppress mitochondrial reactive oxygen species (ROS) production and is employed by drug-resistant cancer cells to mitigate oxidative stress. Using the drug-sensitive HL-60 cells and the drug-resistant MX2 subline as model systems, we show that genipin, a UCP2...

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Detalles Bibliográficos
Autores principales: Mailloux, Ryan J., Adjeitey, Cyril Nii-Klu, Harper, Mary-Ellen
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953501/
https://www.ncbi.nlm.nih.gov/pubmed/20967268
http://dx.doi.org/10.1371/journal.pone.0013289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953501/
https://www.ncbi.nlm.nih.gov/pubmed/20967268
http://dx.doi.org/10.1371/journal.pone.0013289

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