Novel HTS Strategy Identifies TRAIL-Sensitizing Compounds Acting Specifically Through the Caspase-8 Apoptotic Axis

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) is potentially a very important therapeutic as it shows selectivity for inducing apoptosis in cancer cells whilst normal cells are refractory. TRAIL binding to its cognate receptors, Death Receptors-4 and -5, leads to recruitment of cas...

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Detalles Bibliográficos
Autores principales: Finlay, Darren, Richardson, Robyn D., Landberg, Lisa K., Howes, Amy L., Vuori, Kristiina
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953515/
https://www.ncbi.nlm.nih.gov/pubmed/20967281
http://dx.doi.org/10.1371/journal.pone.0013375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953515/
https://www.ncbi.nlm.nih.gov/pubmed/20967281
http://dx.doi.org/10.1371/journal.pone.0013375

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