Cargando…

Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development

BH3-only proteins, such as Bim and Bad, contribute to tissue homeostasis by initiating apoptosis in a cell type- and stimulus-specific manner. Loss of Bim provokes lymphocyte accumulation in vivo and renders lymphocytes more resistant to diverse apoptotic stimuli and Bad has been implicated in the a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kelly, PN, White, MJ, Goschnick, MW, Fairfax, KA, Tarlinton, DM, Kinkel, SA, Bouillet, P, Adams, JM, Kile, BT, Strasser, A
Formato:	Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953537/ https://www.ncbi.nlm.nih.gov/pubmed/20431598 http://dx.doi.org/10.1038/cdd.2010.43

Ejemplares similares

Role of BH3-only protein Bim in autoimmune and degenerative diseases
por: Bouillet, P, et al.
Publicado: (2003)

Loss of the Pro-Apoptotic BH3-only Bcl-2 Family Member Bim Inhibits BCR Stimulation–induced Apoptosis and Deletion of Autoreactive B Cells
por: Enders, Anselm, et al.
Publicado: (2003)

Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax
por: McKenzie, Mark D., et al.
Publicado: (2010)

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins
por: Mérino, Delphine, et al.
Publicado: (2009)

BH3-only proteins, Bmf and Bim, in autophagy
por: Delgado, Monica, et al.
Publicado: (2013)

BH3-Only Protein BIM Mediates Heat Shock-Induced Apoptosis
por: Mahajan, Indra M., et al.
Publicado: (2014)

Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner
por: Liu, Rui, et al.
Publicado: (2018)

AMP kinase–mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis
por: Concannon, Caoimhín G., et al.
Publicado: (2010)

Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction
por: Erlacher, Miriam, et al.
Publicado: (2006)

The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL
por: Delbridge, Alex RD, et al.
Publicado: (2017)

BH3-Only Molecule Bim Mediates β-Cell Death in IRS2 Deficiency
por: Ren, Decheng, et al.
Publicado: (2014)

The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland
por: Schuler, F, et al.
Publicado: (2016)

The BH3-only protein Bad is dispensable for TNF-mediated cell death
por: Ottina, E, et al.
Publicado: (2015)

The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity
por: Wali, J A, et al.
Publicado: (2014)

Haematopoietic stem cell survival and transplantation efficacy is limited by the BH3-only proteins Bim and Bmf
por: Labi, Verena, et al.
Publicado: (2013)

Role of BH3-Only Molecules Bim and Puma in β-Cell Death in Pdx1 Deficiency
por: Ren, Decheng, et al.
Publicado: (2014)

Correction to: The BH3-only protein Bad is dispensable for TNF-mediated cell death
por: Ottina, E., et al.
Publicado: (2018)

The Pro-Apoptotic BH3-Only Protein Bim Interacts with Components of the Translocase of the Outer Mitochondrial Membrane (TOM)
por: Frank, Daniel O., et al.
Publicado: (2015)

Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates γ irradiation–induced thymic lymphoma development
por: Labi, Verena, et al.
Publicado: (2008)

BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway
por: Craxton, Andrew, et al.
Publicado: (2005)

BH3-only sensors Bad, Noxa and Puma are Key Regulators of Tacaribe virus-induced Apoptosis
por: Holzerland, Julia, et al.
Publicado: (2020)

BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus
por: Bunk, E C, et al.
Publicado: (2010)

The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist
por: Rautureau, G J P, et al.
Publicado: (2012)

Heat shock preconditioning protects against ER stress-induced apoptosis through the regulation of the BH3-only protein BIM
por: Kennedy, Donna, et al.
Publicado: (2014)

Gefitinib-Induced Killing of NSCLC Cell Lines Expressing Mutant EGFR Requires BIM and Can Be Enhanced by BH3 Mimetics
por: Cragg, Mark S, et al.
Publicado: (2007)

Synergistic induction of cell death in liver tumor cells by TRAIL and chemotherapeutic drugs via the BH3-only proteins Bim and Bid
por: Schneider-Jakob, S, et al.
Publicado: (2010)

Combined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in TACI-Ig transgenic mice
por: Woess, C, et al.
Publicado: (2015)

Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM
por: Tomicic, Maja T., et al.
Publicado: (2015)

Garlic arrests MDA-MB-435 cancer cells in mitosis, phosphorylates the proapoptotic BH3-only protein Bim(EL) and induces apoptosis
por: Lund, T, et al.
Publicado: (2005)

Minor cell death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf
por: Baumgartner, Florian, et al.
Publicado: (2012)

Loss of Bim Increases T Cell Production and Function in Interleukin 7 Receptor–deficient Mice
por: Pellegrini, Marc, et al.
Publicado: (2004)

Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice
por: Herold, M J, et al.
Publicado: (2014)

Preferential targeting of MCL-1 by a hydrocarbon-stapled BIM BH3 peptide
por: Hadji, Abbas, et al.
Publicado: (2019)

Apoptosis Regulators Fas and Bim Cooperate in Shutdown of Chronic Immune Responses and Prevention of Autoimmunity
por: Hughes, Peter D., et al.
Publicado: (2008)

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein Bim
por: Santin, Izortze, et al.
Publicado: (2011)

Loss of GCN5 leads to increased neuronal apoptosis by upregulating E2F1- and Egr-1-dependent BH3-only protein Bim
por: Wu, Yanna, et al.
Publicado: (2017)

Type I Interferon Drives Dendritic Cell Apoptosis via Multiple BH3-Only Proteins following Activation by PolyIC In Vivo
por: Fuertes Marraco, Silvia A., et al.
Publicado: (2011)

MOMP in the absence of BH3-only proteins
por: García Sáez, Ana J., et al.
Publicado: (2016)

Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction
por: Robin, A Y, et al.
Publicado: (2015)

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis
por: Hutcheson, Jack, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_ucnj2d7cpspdli4lohrfjuvr5k