Endoplasmic Reticulum Stress Mediates Radiation-Induced Autophagy via PERK-eIF2α in Caspase-3/7 Deficient Cells

Since apoptosis defects limit efficacy of anti-cancer agents, autophagy has been proposed as a novel strategy for radiotherapy enhancement. We previously showed that caspase-3/7 inhibition induces autophagy and promotes radiosensitivity in vitro and in vivo. Therefore, we further investigated the me...

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Detalles Bibliográficos
Autores principales: Kim, Kwang Woon, Moretti, Luigi, Mitchell, Lauren R., Jung, Dae Kwang, Lu, Bo
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953962/
https://www.ncbi.nlm.nih.gov/pubmed/20348950
http://dx.doi.org/10.1038/onc.2010.74

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953962/
https://www.ncbi.nlm.nih.gov/pubmed/20348950
http://dx.doi.org/10.1038/onc.2010.74

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