DUFs: families in search of function

Domains of unknown function (DUFs) are a large set of uncharacterized protein families that are found in the Pfam database. Here, the scale and growth of functionally uncharacterized families in biological databases are surveyed and the prospects for discovering their function are examined. In parti...

Descripción completa

Detalles Bibliográficos
Autores principales: Bateman, Alex, Coggill, Penny, Finn, Robert D.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Domains of Unknown Function
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954198/
https://www.ncbi.nlm.nih.gov/pubmed/20944204
http://dx.doi.org/10.1107/S1744309110001685
_version_ 1782187902280663040
author Bateman, Alex
Coggill, Penny
Finn, Robert D.
author_facet Bateman, Alex
Coggill, Penny
Finn, Robert D.
author_sort Bateman, Alex
collection PubMed
description Domains of unknown function (DUFs) are a large set of uncharacterized protein families that are found in the Pfam database. Here, the scale and growth of functionally uncharacterized families in biological databases are surveyed and the prospects for discovering their function are examined. In particular, the important role that structural genomics can play in identifying potential function is evaluated.
format Text
id pubmed-2954198
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher International Union of Crystallography
record_format MEDLINE/PubMed
spelling pubmed-29541982010-10-27 DUFs: families in search of function Bateman, Alex Coggill, Penny Finn, Robert D. Acta Crystallogr Sect F Struct Biol Cryst Commun Domains of Unknown Function Domains of unknown function (DUFs) are a large set of uncharacterized protein families that are found in the Pfam database. Here, the scale and growth of functionally uncharacterized families in biological databases are surveyed and the prospects for discovering their function are examined. In particular, the important role that structural genomics can play in identifying potential function is evaluated. International Union of Crystallography 2010-03-05 /pmc/articles/PMC2954198/ /pubmed/20944204 http://dx.doi.org/10.1107/S1744309110001685 Text en © Bateman et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Domains of Unknown Function
Bateman, Alex
Coggill, Penny
Finn, Robert D.
DUFs: families in search of function
title DUFs: families in search of function
title_full DUFs: families in search of function
title_fullStr DUFs: families in search of function
title_full_unstemmed DUFs: families in search of function
title_short DUFs: families in search of function
title_sort dufs: families in search of function
topic Domains of Unknown Function
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954198/
https://www.ncbi.nlm.nih.gov/pubmed/20944204
http://dx.doi.org/10.1107/S1744309110001685
work_keys_str_mv AT batemanalex dufsfamiliesinsearchoffunction
AT coggillpenny dufsfamiliesinsearchoffunction
AT finnrobertd dufsfamiliesinsearchoffunction

Ejemplares similares